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The average daily dose for the barbiturate addict is usually about 1.5 grams. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxicating dosage and fatal dosage becomes smaller.

Barbiturates are absorbed hinein varying degrees following oral, rectal, or parenteral administration. The salts are more rapidly absorbed than are the acids.

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Barbiturates are contraindicated hinein patients with known barbiturate sensitivity. Barbiturates are also contraindicated rein patients with a history of manifest or latent porphyria.

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At the opposite extreme is secobarbital which has the highest lipid solubility, plasma protein binding, brain protein binding, the shortest delay hinein onset of activity, and the shortest duration of action. Butabarbital is classified as an intermediate barbiturate.

In convulsive states, dosage of NEMBUTAL Sodium Solution should Beryllium kept to a minimum to avoid here compounding the depression which may follow convulsions. The injection must be made slowly with due regard to the time required for the drug to penetrate the blood-brain barrier.

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Barbiturates are respiratory depressants. The degree of respiratory depression is dependent upon dose. With hypnotic doses, respiratory depression produced by barbiturates is similar to that which occurs during physiologic sleep with slight decrease in blood pressure and heart Satz.

Duration of action, which is related to the Satz at which the barbiturates are redistributed throughout the body, varies among persons and hinein the same person from time to time.

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In dem injection of the sodium salts of barbiturates should be made deeply into a large muscle, and a volume of 5 mL should not be exceeded at any one site because of possible tissue irritation.